HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 3-(1-Chloroethyl)-4-phenyl-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 3-(1-Hydroxyethyl)-4-phenyl-1H-isochromen-1-one | HCID 118131164 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(1-Chloroethyl)-4-phenyl-1H-isochromen-1-one | HCID 118131454 | 49.8% |
Reaction Steps
3-(1-Hydroxyethyl)-4-phenyl-1H-isochromen-1-one (intermediate B1, 300 mg, 1.27 mmol), Methane sulfonyl chloride (516 mg, 4.51 mmol), TEA (0.62 mmol, 4.5 ml) were reacted in DCM (10 ml) at RT. Solvent was then removed under reduced pressure to give the title compound (180 mg). This was used in next step without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-b8b32a77efcd43ea8edd0c08b5a87a12 |
| Source note | uspto-grants-2016_04 |