反应详情

4-Phenyl-3-propyl-1H-isochromen-1-one (intermediate C20.3, 107 mg, 0.405 mmol), N-bromosuccinimide (86 mg, 0.486 mmol), benzoyl peroxide (25 mg, 0.1 mmol) were reacted in CCl4 (2 mL) at 100° C. for 2 hrs. The reaction mixture was then purified on Biotage 50 g silica gel cartridge with a gradient of hexane and EtOAc to give the title compound (101 mg, 72.7%) as a yellowish oil.

1. customThe reaction mixture was then purified on Biotage 50 g silica gel cartridge with a gradient of hexane and EtOAc