N,N-Dimethylglycine → 3-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(1-(2-(dimethylamino)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-isochromen-1-one formate

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Reaction Steps

Title compound was prepared following the procedure used for the synthesis of Intermediate D25, from 3-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(1,2,3,6-tetrahydropyridin-4-yl)-1H-isochromen-1-one hydrochloride (Intermediate Intermediate D23, 0.200 g, 0.363 mmol) and 2-(dimethylamino)acetic acid (0.045 g, 0.436 mmol) to give the title compound (0.127 g, 0.197 mmol, 54.2% yield) as a white powder.

Provenance & Evidence