HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → tert-butyl 1-(1-oxo-4-phenyl-1H-isochromen-3-yl)ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | tert-butyl 1-(4-bromo-1-oxo-1H-isochromen-3-yl)ethylcarbamate | HCID 118131111 | — |
| Reactant | 3-(1-Hydroxyethyl)-4-phenyl-1H-isochromen-1-one | HCID 118131164 | — |
| Product | tert-butyl 1-(1-oxo-4-phenyl-1H-isochromen-3-yl)ethylcarbamate | HCID 118131293 | 22.6% |
Reaction Steps
The title compound was made in a way similar to that of intermediate B1 from tert-butyl 1-(4-bromo-1-oxo-1H-isochromen-3-yl)ethylcarbamate (Intermediate A3, 500 mg, 1.358 mmol), phenylboronic acid (215 mg, 1.765 mmol), to give the title compound (112 mg, 22.6%) as a yellowish oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-8ba473e6d66d49c5be410ed3e1eeebc0 |
| Source note | uspto-grants-2016_04 |