3,4-dihydro-2H-pyran → HCID 118131366, compound

Participants

Reaction Conditions

Reaction Steps

to a solution of 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1 g, 3.83 mmol) in dry DMF (15 mL), 3,4-dihydro-2H-Pyran (1.103 ml, 11.49 mmol) and 4-methylbenzenesulfonic acid monohydrate (0.208 ml, 0.958 mmol) were added. The solution was stirred for 5 days at 90° C. Solvent was removed and product was purified by Biotage Si 25 g with a gradient of heptane and ethyl acetate to give the title compound (320 mg, 19.5% yield).

Provenance & Evidence