HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-((6-Amino-9H-purin-9-yl)methyl)-4-(2-fluorophenyl)-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Bromomethyl)-4-(2-fluorophenyl)-1H-isochromen-1-one | HCID 118131273 | — |
| Reactant | HCID 178508693 | HCID 178508693 | — |
| Product | 3-((6-Amino-9H-purin-9-yl)methyl)-4-(2-fluorophenyl)-1H-isochromen-1-one | HCID 118131102 | 64.5% |
Reaction Steps
The title compound was made in a similar way as that of the compound of example 1, using 3-(bromomethyl)-4-(2-fluorophenyl)-1H-isochromen-1-one (intermediate C2, 60 mg, 0.180 mmol), 9H-purin-6-amine (48.7 mg, 0.360 mmol) and K2CO3 (49.8 mg, 0.360 mmol) to give the title compound (45 mg, 64.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-2a0c497027ae424baf8f1781719a3f9b |
| Source note | uspto-grants-2016_04 |