HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-(1-(6-Amino-9H-purin-9-yl)ethyl)-4-(3-fluorophenyl)-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(1-Bromoethyl)-4-(3-fluorophenyl)-1H-isochromen-1-one | HCID 118131080 | — |
| Reactant | HCID 178508693 | HCID 178508693 | — |
| Product | 3-(1-(6-Amino-9H-purin-9-yl)ethyl)-4-(3-fluorophenyl)-1H-isochromen-1-one | HCID 118131207 | 37.1% |
Reaction Steps
The title compound was made in a similar way as that of the compound of example 1, using 3-(1-bromoethyl)-4-(3-fluorophenyl)-1H-isochromen-1-one (intermediate C6, 70 mg, 0.202 mmol), 9H-purin-6-amine (54.5 mg, 0.403 mmol) and K2CO3 (55.7 mg, 0.403 mmol) to give the title compound (30 mg, 37.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a3453c7a55a94358b7c47c65ed386934 |
| Source note | uspto-grants-2016_04 |