Potassium Carbonate → HCID 118131120, compound

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Reaction Steps

The title compound was made in a similar way as that of the compound of example 1, using 3-(1-bromoethyl)-4-(3-(morpholinosulfonyl)phenyl)-1H-isochromen-1-one (intermediate C9, 68 mg, 0.142 mmol), 9H-purin-6-amine (57.6 mg, 0.426 mmol) and K2CO3 (29.5 mg, 0.213 mmol) to give the title compound (30 mg, 37.1%). The resulting mixture was straightforward purified via reverse phase chromatography with a Biotage C18 SNAP column (Phase A, water 95%, ACN 5%, formic acid 0.1%); Phase B ACN 95%, water 5%, formic acid 0.1%) The resulting product was further purified by Preparative HPLC (method 2) to give the chemically pure compound (10 mg, 13%) and a batch with lower purity (9 mg, 12%).

Provenance & Evidence