Acetic Acid → HCID 178438188, compound

Participants

Reaction Conditions

Reaction Steps

3-(1-(4-amino-3-(6-methoxypyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one (Example 60, 28 mg, 0.057 mmol) was dissolved in HBr 33% in CH3COOH (2 ml, 36.8 mmol) and stirred at 60° C. for 4 hr. The reaction was then diluted with 3 ml of water and the resulting mixture purified via reverse phase chromatography using a Biotage C18 30 g SNAP with a gradient of water and acetonitrile to give the title compound (6.9 mg, 25.4%) as yellowish solid.

Provenance & Evidence