Acetic Anhydride → HCID 118131309, compound

Participants

Reaction Steps

3-(1-(4-amino-3-(2-aminothiazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one hydrochloride (Example 59, 23 mg, 0.044 mmol) was dissolved in TEA (124 μL, 0.888 mmol)/Ac2O (419 μL, 4.44 mmol) and stirred at rt for 1 h. The reaction mixture was quenched by the addition of 1M HCl (1 ml) and purified via reverse phase chromatography using a Biotage C18 30 g SNAP with a gradient of water and acetonitrile to give the title compound (2.3 mg, 9.9%) as yellowish solid.

Provenance & Evidence