3-Fluoro-5-hydroxybenzeneboronic acid → 4-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(1-(4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-isochromen-1-one

Participants

Reaction Steps

The title compound was mane in a similar way as that or the compound of example 51 from 4-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1H-isochromen-1-one (Intermediate D12, 1.08 g, 1.941 mmol), (3-fluoro-5-hydroxyphenyl)boronic acid (0.605 g, 3.88 mmol), to give the title compound (456 mg, 43.5%) as a pale grey solid.

Provenance & Evidence