HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1-aminoethyl)-4-phenyl-1H-isochromen-1-one hydrochloride → 4-phenyl-3-(1-(pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)ethyl)-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1-aminoethyl)-4-phenyl-1H-isochromen-1-one hydrochloride | HCID 118131463 | — |
| Reactant | 4-(1H-pyrazol-4-yl)-3-(1-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)-1H-isochromen-1-one hydrochloride | HCID 118131479 | — |
| Product | 4-Chloropyrrolo(2,1-f)(1,2,4)triazine | HCID 21081683 | — |
| Product | 4-phenyl-3-(1-(pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)ethyl)-1H-isochromen-1-one | HCID 118131209 | 79% |
| Product | 3-(1-aminoethyl)-4-phenyl-1H-isochromen-1-one hydrochloride | HCID 118131463 | — |
Reaction Steps
The title compound was made in a similar way as that of the compound of example 80, from 3-(1-aminoethyl)-4-phenyl-1H-isochromen-1-one hydrochloride (Intermediate E2, 50 mg, 0.166 mmol) and 4-chloropyrrolo[2,1-f][1,2,4]triazine (35.6 mg, 0.232 mmol) to give the title compound (50.3 mg, 79%) as whitish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a292b1cad9364623a3177a2a2310144c |
| Source note | uspto-grants-2016_04 |