3-(1-(4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one → N-(5-(4-amino-1-(1-(1-oxo-4-phenyl-1H-isochromen-3-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

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Reaction Steps

The title compound was made in a similar way as that of the compound of example 52 from 4-fluoro-N-(5-(trimethylstannyl)pyridin-3-yl)benzenesulfonamide (Intermediate G9, 98 mg, 0.236 mmol) and 3-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one (intermediate D2a, 60 mg, 0.118 mmol) affording the title compound (13 mg, 0.021 mmol, 17.4% yield) as white solid

Provenance & Evidence