反应详情

Title compound was prepared following the procedure described for the synthesis of Intermediate D1, from 3-(3-fluoro-5-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (Intermediate G1, 52.4 mg, 0.202 mmol) and benzyl 3-(3-(1-bromoethyl)-1-oxo-1H-isochromen-4-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate (Intermediate C40, 100 mg, 0.202 mmol) to give Benzyl 3-(3-(1-(4-amino-3-(3-fluoro-5-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1-oxo-1H-isochromen-4-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate (125 mg, 0.186 mmol, 92% yield) as a yellow solid.

1. customTitle compound was prepared