3-(1-Bromoethyl)-4-phenyl-1H-isochromen-1-one → 3-(1-(4-amino-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one

Participants

Reaction Steps

The title compound was made in a similar way as that of the compound of example 1 using 3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (Intermediate G16, 45 mg, 0.222 mmol) 3-(1-bromoethyl)-4-phenyl-1H-isochromen-1-one (intermediate C7, 72.9 mg, 0.222 mmol). to give the title compound (15 mg, 0.033 mmol, 15.0% yield) as white solid.

Provenance & Evidence