4-(trimethylstannyl)-1H-indazole → 3-(1-(4-amino-3-(1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one

Participants

Role	Name	HCID	Charge
Reactant	4-(trimethylstannyl)-1H-indazole	HCID 58441396	—
Reactant	3-(1-(4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one	HCID 118131053	—
Reactant	3-(1-(4-amino-3-(pyrazin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one	HCID 118131283	—
Product	3-(1-(4-amino-3-(1H-indazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one	HCID 118131058	39%

Reaction Steps

The title compound was made in a similar way as that of the compound of example 52 from 3-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-phenyl-1H-isochromen-1-one (intermediate D2a, 50 mg, 0.098 mmol), and 4-(trimethylstannyl)-1H-indazole (Intermediate G19, 41.4 mg, 0,147 mmol) to give the title compound (19 mg, 39%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09321776B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-d6db3cd14b5845dd9533a61955c6d031
Source note	uspto-grants-2016_04