3-(1-(4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(5-(piperazin-1-ylmethyl)thiophen-2-yl)-1H-isochromen-1-one dihydrochloride → 3-(1-(4-amino-3-(3-(benzyloxy)-5-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(5-(3-(dimethylamino)prop-1-en-1-yl)thiophen-2-yl)-1H-isochromen-1-one

참여 물질

반응 단계

The title compound was made in a similar way as that of the compound of example 134, step a, from 4-(5-(3-(dimethylamino)prop-1-en-1-yl)thiophen-2-yl)-3-(1-hydroxyethyl)-1H-isochromen-1-one (Intermediate B40, 220 mg, 0,619 mmol), and 3-(3-(benzyloxy)-5-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (Intermediate G18, 125 mg, 0.37 mmol) to give 3-(1-(4-amino-3-(3-(benzyloxy)-5-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(5-(3-(dimethylamino)prop-1-en-1-yl)thiophen-2-yl)-1H-isochromen-1-one (180 mg, 0,268 mmol, 43.2% yield) as a brown oil.

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