反应详情

The title compound was made in a similar way as that of the example 134, step a, from 3-(1-hydroxyethyl)-4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-isochromen-1-one (Intermediate B47, 380 mg, 1.088 mmol) and 3-(3-fluoro-5-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (Intermediate G1, 310 mg, 1.197 mmol) to give 3-(1-(4-amino-3-(3-fluoro-5-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-isochromen-1-one (170 mg, 0.288 mmol, 26.5% yield) as a brown solid.