Cyclopropanecarboxaldehyde → 3-(1-(4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(1-(1-(cyclopropylmethyl)azetidin-3-yl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-isochromen-1-one dihydrochloride

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Reaction Steps

Title compound was prepared following the procedure described for the synthesis of Intermediate D24, from 3-(1-(4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-(1-(azetidin-3-yl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-isochromen-1-one dihydrochloride (Example 156, 35 mg, 0.059 mmol) and cyclopropanecarbaldehyde (10.19 μl 0.136 mmol) to give the compound (33.8 mg, 0.050 mmol, 84% yield) as a white powder.

Provenance & Evidence