反应详情

温度

60 °C

In a 1000 ml pressure resistant flask equipped with a stirrer were charged 100.0 g of ethyl 11-(p-benzyloxyphenoxy)undecanoate synthesized in Synthetic example 1, 3.0 g of a 10% palladium-carbon, 400 ml of 1,4-dioxane and 200 ml of ethanol, and the mixture was heated to 60° C. and under pressurized conditions of an inner vessel pressure at 2.5 kgf/cm2, a hydrogen gas was passed through and the mixture was vigorously stirred for 3 hours. Insolubles were removed by filtration, and the filtrate was concentrated to precipitate crystals. The resulting crystals were washed with cooled n-hexane to obtain 73.4 g of the title compound.

1. customIn a 1000 ml pressure resistant flask equipped with a stirrer
2. customInsolubles were removed by filtration
3. concentrationthe filtrate was concentrated
4. customto precipitate crystals
5. washThe resulting crystals were washed with cooled n-hexane