Morpholine → HCID 54008544, compound

Participants

Reaction Steps

In a 200 ml flask equipped with a stirrer, a condenser and a calcium chloride dryer tube were charged 2.6 g of morpholine and 50 ml of DMAc and the mixture was stirred under ice-cooling. To the solution was gradually added dropwise 7.5 g of 11-decylthioundecanoic acid chloride prepared in Synthetic example 13. After completion of dropwise addition, the mixture was returned to room temperature and further stirred for 2 hours. The reaction solution was diluted with 300 ml of toluene, and washed successively with a 5% aqueous sodium hydrogen carbonate solution, distilled water and a saturated saline solution. The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed under reduced pressure to obtain crystals. The crystals were recrystallized from n-hexane to obtain 6.9 g of the title compound. Melting point: 61° C.

Provenance & Evidence