Hydrochloric Acid → HCID 10959481, compound

Participants

Reaction Steps

The crude 3-[[2-[(5-chloro-2-hydroxyphenyl)carbonyl]-4-(trifluoromethyl)phenyl]amino]-3-oxopropanoic acid, methyl ester prepared in Step B was dissolved in THF (15 mL) and potassium t-butoxide solution (1M in THF, 1.74 mmol, 1.74 mL) was added. The reaction mixture was heated under reflux for 15 minutes. It was then acidified with 1N HCl and the organic layer was separated. The organic layer was washed with water, brine and dried (MgSO4). Evaporation of the solvent gave a yellow solid which was triturated with ethyl acetate/hexanes to afford the title compound as a yellow solid (0.48 g, 83%): mp>250° C. MS m/e 366 (MH+).

Provenance & Evidence