Potassium bis(trimethylsilyl)amide → HCID 10917239, compound

Participants

Reaction Conditions

Reaction Steps

A solution of potassium bis(trimethylsilyl)amide (0.5 M in toluene, 57 mL, 28.5 mmol) was added to a stirred cold (−78° C.) solution of 4-[[2-[(5-chloro-2-methoxyphenyl)carbonyl]-4-(trifluoromethyl)phenyl]amino]-4-oxobutanoic acid, methyl ester prepared in Step A (4.05 g, 9.1 mmol) in anhydrous THF (25 mL) and maintained at −78° C. for 3 hours. Acidic work-up with 1N HCl and followed by extraction with EtOAc afforded the crude title compound (4.05 g, 100%).

Provenance & Evidence