Hydrochloric Acid → HCID 21260392, compound

Participants

Reaction Conditions

Reaction Steps

A neat mixture of crude 4-(5-chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolineacetic acid prepared in Step C (1.45 g, 3.5 mmol) and pyridinium hydrochloride (5 g, 43.3 mmol) was heated at 185° C. for 3 hours. Reaction mixture was allowed to cool and 1N HCl was added and then extracted with EtOAc to afford the title compound (1.20 g, 86%): mp 158-160° C.;

Provenance & Evidence