HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one | HCID 135404718 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride | HCID 22030836 | — |
Reaction Steps
A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (2.82 g, 0.01 mol), thionyl chloride (40 ml) and DMF (0.28 ml) was stirred and heated at reflux for 1 hour. The mixture was evaporated and azeotroped with toluene to give 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (3.45 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06184225B2 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-f6596a4331cb45bda433cfeb833af38c |
| Source note | uspto-grants-2001_02 |