Acetic Anhydride → HCID 21260325, compound

Participants

Reaction Steps

Triethylamine (216 ml, 1.5 mmol) and then acetic anhydride (133 ml, 1.4 mmol) were added to a stirred suspension of 7-benzyloxy-4-(4-chloro-2-fluoro-5-hydroxyanilino)-6-methoxy quinazoline hydrochloride (600 mg, 1.4 mmol) in methylene chloride (7 ml). The mixture was stirred at ambient temperature for 3 hours and insoluble material removed by filtration. Volatiles were removed from the filtrate by evaporation and the residue purified by flash chromatography eluting with methylene chloride/methanol (100/0 increasing in polarity to 97/3) to give 4-(5-acetoxy-4-chloro-2-fluoroanilino)-7-benzyloxy-6-methoxyquinazoline (340 mg, 52%) as a solid.

Provenance & Evidence