5-Amino-4-fluoro-2-methylphenol → HCID 21260334, compound

Participants

Reaction Steps

A mixture of 4-chloro-6,7-dimethoxyquinazoline hydrochloride (2.5 g, 9.6 mmol), (prepared as described for the starting material in Example 1 but without the aqueous work up), and 2-fluoro-5-hydroxy-4-methylaniline (1.48 g, 10.5 mmol) in isopropanol (150 ml) was heated at reflux for 2 hours. The mixture was allowed to cool, the solid product collected by filtration, washed with isopropanol and dried to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxyquinazoline hydrochloride (2.2 g, 71 %).

Provenance & Evidence