5-Amino-4-fluoro-2-methylphenol → 4-(2-Fluoro-5-hydroxy4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)quinazoline hydrochloride

Participants

Reaction Steps

A mixture of 4-chloro-6-methoxy-7-(2-methoxyethoxy)quinazoline (76 mg, 0.28 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (40 mg, 0.28 mmol), (prepared as described for the starting material in Example 8), in isopropanol (2.5 ml) was stirred and heated at reflux for 7 hours. The reaction mixture was allowed to cool and the precipitated product collected by filtration, washed with isopropanol and dried to give 4-(2-fluoro-5-hydroxy4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)quinazoline hydrochloride (79 mg 66%) as a white solid.

Provenance & Evidence