4-Bromo-2,6-difluoroaniline → HCID 21260300, compound

Participants

Reaction Steps

A mixture of 4-chloro-6,7-dimethoxyquinazoline hydrochloride, (152 mg, 0.6 mmol), (prepared as described for the starting material in Example 1 but without the aqueous work up), and 4-bromo-2,6-difluoroaniline (121 mg, 0.6 mmol) in isopropanol (7 ml) was heated at reflux for 2 hours. The mixture was allowed to cool, the solid product collected by filtration, washed with isopropanol and dried to give 4-(4-bromo-2,6-difluoroanilino)-6,7-dimethoxyquinazoline hydrochloride (81 mg, 35%).

Provenance & Evidence