HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Chloro-2,6-difluoroaniline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl (4-chloro-2,6-difluorophenyl)carbamate | HCID 21260314 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Chloro-2,6-difluoroaniline hydrochloride | HCID 21260280 | 107.7% |
Reaction Steps
A saturated solution of hydrogen chloride in ethyl acetate (4 ml) was added to N-t-butoxycarbonyl-4-chloro-2,6-difluoroaniline (330 mg, 1.3 mmol) and the mixture stirred at ambient temperature for 2 hours. The precipitate was collected by filtration to give 4-chloro-2,6-difluoroaniline hydrochloride (140 mg, 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06184225B2 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-1b183999590949a6af8eb197931caed8 |
| Source note | uspto-grants-2001_02 |