Potassium Carbonate → 6-Methoxy-7-(3-morpholinopropoxy)-4-phenoxyquinazoline

Participants

Reaction Conditions

Reaction Steps

4-(3-Chloropropyl)morpholine (0.9 g, 4.5 mmol), (J. Am- Chem. Soc. 1945, 67, 736, 174 mg, 1.06 mmol), was added to 7-hydroxy-6-methoxy-4-phenoxyquinazoline (1.0 g, 3.7 mmol), potassium carbonate (2.6 g, 18.8 mmol) in DMF (30 ml). The mixture was heated at 110° C. for 4 hours and then allowed to cool. The solids were removed by filtration, and the volatiles were removed from the filtrate by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol, (96/4) to give 6-methoxy-7-(3-morpholinopropoxy)-4-phenoxyquinazoline (1.0 g, 68%).

Provenance & Evidence