Hydrochloric Acid → 6-Methoxy-7-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-methoxy-7-(3-morpholinopropoxy)-4-phenoxyquinazoline (980 mg, 2.48 mmol) and 2M hydrochloric acid (25 ml) was heated at 100° C. for 2 hours and allowed to cool. The solution was basified with solid sodium hydrogen carbonate, and the product was extracted with methylene chloride. The organic phase was passed through phase separating paper and the solvent removed by evaporation to give 6-methoxy-7-(3-morpholinopropoxy)-3,4dihydroquinazolin-4-one (750 mg, 95%) as a pale brown solid which was used without further purification.

Provenance & Evidence