反应详情

A mixture of 1-methylpiperazine (7 ml) and 7-(2-bromoethoxy)-6-methoxy4-phenoxyquinazoline (1.0 g, 2.67 mmol), (prepared as described for the starting material in Example 22), was stirred at ambient temperature for 5 hours. The excess 1-methylpiperazine was removed by evaporation and the residue was partitioned between aqueous sodium hydrogen carbonate and methylene chloride. The organic phase was separated, passed through phase separating paper and the volatiles removed by evaporation to give 6-methoxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)-4-phenoxyquinazoline (970 mg, 92%).

1. custom(prepared
2. customThe excess 1-methylpiperazine was removed by evaporation
3. customthe residue was partitioned between aqueous sodium hydrogen carbonate and methylene chloride
4. customThe organic phase was separated
5. customseparating paper
6. customthe volatiles removed by evaporation