5-Amino-4-fluoro-2-methylphenol → HCID 86756355, compound

Participants

Reaction Steps

A solution of 4-chloro-7-(2-methoxyethoxy)quinazoline hydrochloride (275 mg, 1 mmol) and 2-fluoro-5-hydroxy4-methylaniline (170 mg, 1.2 mmol), (prepared as described for the starting material in Example 8), in 2-pentanol (5 ml) was heated at reflux for 2 hours. The mixture was allowed to cool and the precipitate was collected by filtration, washed with isopropanol and ether, and dried under vacuum at 70° C. to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-7-(2-methoxyethoxy)quinazoline hydrochloride(295 mg, 78%) as a cream solid.

Provenance & Evidence