反应详情

A solution of 3,4-dihydro-6-methoxy-3-((pivaloyloxy)methyl)-7-(3-morpholinopropoxy)quinazolin-4-one (4.93 g, 11.4 mmol) in a saturated solution of methanolic ammonia (70 ml) was stirred at ambient temperature for 2 days. The volatiles were removed by evaporation. The solid residue was suspended in ether, collected by filtration, washed with ether and dried under vacuum to give 4-hydroxy-6-methoxy-7-(3-morpholinopropoxy)quinazoline (2.87 g, 79%).

1. customThe volatiles were removed by evaporation
2. filtrationcollected by filtration
3. washwashed with ether
4. customdried under vacuum