HCID 21260458, compound → HCID 21260528, compound

HRID 634758Notes

Reaction equation

HRID 634758 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]2[NH:15][CH2:16][CH2:17][CH:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)C)=[CH:5][CH:4]=1.[C:26]1(C(C)CCNC2CCCCC2C2C=CC(O)=CC=2)C=CC=CC=1>>[C:25]1([CH2:20][CH2:18][CH2:17][CH2:16][NH:15][CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]2[C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:26]=1

Participants

3

Reactant 2

HCID 21260458HCID 21260458, compoundHCID 21260553HCID 21260553, compound

Product 1

HCID 21260528HCID 21260528, compound

Procedure

Following the general method of example 1 (2RS,3SR)-[2-(4-methoxy-phenyl)-cyclohexyl]-(3-phenyl-butyl)-amine (0.95 g, 2.81 mmol) was converted to (1RS,2SR)-4-[2-(3-phenyl-butylamino)-cyclohexyl]-phenol, giving 0.45 g of a light brown solid. MS: m/e=324.3 (M+H+).

Sources & evidence

ORD record
ord-c6c4d29eafbc4bf08f6b6a7a82e81c53
Source dataset
uspto-grants-2001_02
Patent number
US06184236B2

Reaction notes

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