HRID634761

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：c1ccc(CCCN[C@H]2CC[C@H](c3ccc(OCc4ccccc4)cc3)CC2)cc1

HCID178420266

未命名化合物

PRODUCTS

生成物

结构：Oc1ccc([C@H]2CC[C@H](NCCCc3ccccc3)CC2)cc1

HCID178516054

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of trans-[4-(4-benzyloxy-phenyl)-cyclohexyl]-(3-phenyl-propyl)-amine (200 mg, 0.5 mmol), Pd/C 10% (20 mg) and MeOH (20 ml) was hydrogenated at RT for 3 h. Removal of the catalyst and evaporation of the solvent left a residue which after trituration with ether gave trans-4-[4-(3-phenyl-propylamino)-cyclohexyl]-phenol (130 mg, 84%) as a white crystalline material. MS: m/e=310.3 (M+H+).

WORKUP

后处理

customRemoval of the catalyst and evaporation of the solvent
waitleft a residue which after trituration with ether