Trifluoroacetic acid → HCID 15290860, compound

Participants

Reaction Steps

A mixture of (1,4-dioxa-spiro[4.5]dec-8-yl)-(3-phenyl-propyl)-amine hydrochloride (1:1) (3.35 g, 10.7 mmol), H2O (25 ml) and trifluoroacetic acid (2.47 ml, 32.2 mmol) was left at r.t for 48 h. NaHCO3 (10%, 100 ml) was added and the solution was extracted with CH2Cl2. Drying of the organic layer (Na2SO4) and evaporation left 4-(3-phenyl-propylamino)-cyclohexanone as a slightly coloured oil (2.4 g, 97%, MS: m/e=232.2 (M+H+)).

Provenance & Evidence