Aluminium lithium hydride → [1-(4-Methoxy-phenyl)-piperidin-4-yl]-(3-phenyl-propyl)-amine

Participants

Role	Name	HCID	Charge
Reactant	Aluminium lithium hydride	HCID 21226445	—
Reactant	N-[1-(4-methoxy-phenyl)-piperidin-4-yl]-3-phenyl-propionamide	HCID 21260533	—
Product	[1-(4-Methoxy-phenyl)-piperidin-4-yl]-(3-phenyl-propyl)-amine	HCID 21260562	91.4%

Reaction Steps

Following the general procedure of example 40b, N-[1-(4-methoxy-phenyl)-piperidin-4-yl]-3-phenyl-propionamide (1.87 g, 5.53 mmol) was reduced with LiAlH4 to give [1-(4-methoxy-phenyl)-piperidin-4-yl]-(3-phenyl-propyl)-amine (1.64 g, 91%, MS: m/e=325.4 (M+H+)) as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06184236B2
Source dataset	uspto-grants-2001_02
ORD ID	ord-780e230ef8a74c398646c18afddb9408
Source note	uspto-grants-2001_02