HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenepropanoic acid → N-[1-(4-methoxy-phenyl)-piperidin-4-yl]-3-phenyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenepropanoic acid | HCID 107 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1-(4-Methoxyphenyl)piperidin-4-amine | HCID 24690205 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[1-(4-methoxy-phenyl)-piperidin-4-yl]-3-phenyl-propionamide | HCID 21260533 | 76.1% |
Reaction Steps
A mixture of 3-phenyl propionic acid (360 mg, 2.4 mmol), CDI (410 mg, 2.5 mmol) and DMF (20 ml) was stirred at 50° for 1 h. After cooling to 0°, 1-(4-methoxy-phenyl)-piperidin-4-ylamine (500 mg, 2.4 mmol) was added and stirring continued for 1 h. After the addition of H2O (60 ml) the white precipitate was collected to give N-[1-(4-methoxy-phenyl)-piperidin-4-yl]-3-phenyl-propionamide (618 mg, 76%, MS: m/e=339.3 (M+H+)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06184236B2 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-fdfe3c29db0143799b56a88a8ba25bb0 |
| Source note | uspto-grants-2001_02 |