Aluminium lithium hydride → HCID 21260484, compound

HRID 634784Notes

Reaction equation

HRID 634784 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][CH:18]([NH:21][C:22](=O)[CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21260509HCID 21260509, compound

Product 1

HCID 21260484HCID 21260484, compoundYield 34%

Procedure

Following the procedure of example 40b, N-[1-(4-benzyloxy-phenyl)-piperidin-4-yl]-2-phenyl-acetamide (200 mg) was reduced with LiAlH4 to give [1-(4-benzyloxy-phenyl)-piperidin-4-yl]-phenethyl-amine (65 mg; 34%) as a white solid (MS: m/e=387.3 (M+H+)).

Sources & evidence

ORD record
ord-d25a98ac4d9144769005f8cb162b5b46
Source dataset
uspto-grants-2001_02
Patent number
US06184236B2

Reaction notes

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