Hydrochloric Acid → 4-[4-(4-Methoxyphenyl)sulfonylaminomethylbenzyl]-nitrobenzene

Participants

Reaction Steps

4-(4-Aminomethylbenzyl)-nitrobenzene (500 mg) was dissolved in dichloromethane (7 mL) and heated with 4-methoxybenzenesulfonyl chloride (426 mg) and triethylamine (0.3 mL). The mixture was stirred at room temperature for 15 hours, poured into dilute aqueous hydrochloric acid, and extracted with dichloromethane (3×). The solvent was evaporated to give 4-[4-(4-methoxyphenyl)sulfonylaminomethylbenzyl]-nitrobenzene as a yellow solid (851 mg, ˜100%), and was used in the next step without further purification.

Provenance & Evidence