Dicyclohexylcarbodiimide → HCID 54702828, compound

Participants

Reaction Steps

1.50 g (9.73 mmol) of the 4,5-dimethyl-2-furanacetic acid, 1.22 g (9.67 mmol) of 4-hydroxy-6-methyl-2-pyrone and 2.22 g (10.7 mmol) of DCC were suspended in 30 ml of chloroform, then 244 mg (2.0 mmol) of DMAP added and stirring carried out overnight at 60° C. The reaction liquid was cooled to room temperature and the insoluble material filtered off. The mother liquor was then concentrated and the residue purified by column chromatography. The solid obtained was recrystallized from diethyl ether, and Compound 7 (488 mg, 186 mmol, 19%) obtained. This was converted to the sodium salt with an equivalent quantity of sodium hydrogen carbonate.

Provenance & Evidence