Dicyclohexylcarbodiimide → HCID 54710609, compound

Participants

Reaction Steps

The 2.49 g (14.8 mmol) of 5-acetyl-2-furanacetic acid, 1.87 g (14.8 mmol) of 4-hydroxy-6-methyl-2-pyrone and 3.37 g (16.3 mmol) of DCC were suspended in 25 ml of chloroform, then 183 mg (1.50 mmol) of DMAP added and stirring carried out overnight at 60° C. The reaction liquid was cooled to room temperature and the insoluble material filtered off. The mother liquor was concentrated and the residue purified by column chromatography. The solid obtained was recrystallized from ethanol and Compound 13 (496 mg, 1.79 mmol, 12%) obtained. This was converted to the sodium salt with an equivalent quantity of sodium hydrogen carbonate.

Provenance & Evidence