HCID 21260719, compound → 2-(3-bromothiophen-2-yl)acetic acid

HRID 634847Notes

Reaction equation

HRID 634847 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH2:7][C:8]([O:10]CC)=[O:9]>[OH-].[Na+]>[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH2:7][C:8]([OH:10])=[O:9]

Participants

3

Reactant 1

HCID 21260719HCID 21260719, compound

Product 1

HCID 212607352-(3-bromothiophen-2-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

10% aqueous sodium hydroxide solution (100 ml) was added to this ester and stirring carried out for 14 hours at 50° C., after which ether extraction was carried out and unnecessary organic material eliminated. Next, acidification was performed with dilute hydrochloric acid and extraction carried out with dichloromethane. After drying, the solvent was distilled off and there was obtained 3-bromo-2-thiopheneacetic acid (4.7 g).

Workup

  1. extractionafter which ether extraction
  2. extractionNext, acidification was performed with dilute hydrochloric acid and extraction
  3. customAfter drying
  4. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-04e9f233557a4d95874c8a52bf6bbdfa
Source dataset
uspto-grants-2001_02
Patent number
US06184245B2

Reaction notes

Loading…