Propyl chloroformate → HCID 54711862, compound

Participants

Reaction Conditions

Reaction Steps

A chloroform (100 ml) solution of 4-hydroxy-6-methyl-3-propoxycarbonyl-2-pyrone (6.0 g, 28.3 mmol), synthesized from 4-hydroxy-6-methyl-2-pyrone and propyl chloroformate, was ice cooled, and a chloroform (100 ml) solution of bromine (4.0 ml, 78 mmol) and iodine (140 mg, 0.55 mmol) slowly added dropwise. After stirring for 7 days at 5° C., an aqueous sodium thiosulphate solution was added and separation performed. After drying and concentrating, crystallization was performed from ethanol and there was obtained the bromo-derivative, 5-bromo-4-hydroxy-6-methyl-3-propoxycarbonyl-2-pyrone (3.36 g, 41%), as white crystals.

Provenance & Evidence