Sodium Methoxide → HCID 54486594, compound

Participants

Reaction Steps

Benzyl 3,4-di-O-acetyl-2,6-dideoxy-2-fluoro-β-L-talopyranoside (1.66 g) obtained in Example 1-(1) above was suspended in 50 ml of anhydrous methanol. The resulting suspension was added with 0.5 ml of a solution of 4.9 M sodium methoxide in methanol and then stirred at room temperature for 30 minutes to effect the reaction intended. The homogenous reaction solution so obtained was neutralized by addition thereto of an ion-exchange resin, Dowex 50 W×2 (H+-form) and then filtered to remove the resin therefrom. The filtrate obtained was concentrated to a small volume and the concentrated solution was allowed to stand at −10° C. and the deposited needles were separated by filtration, affording 1.11 g (yield 89%) of the titled Compound (4).

Provenance & Evidence