反应详情

To a suspension of 2′-amino,2′-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2′-trifluoroacetylamino,2′-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra).

1. customNitrogen was bubbled through the reaction mixture for 2 h
2. customto remove volatile thio-byproducts
3. customThe mixture was evaporated to dryness
4. customthe solid was recrystallized from methanol/chloroform