反应详情

To a solution of N-[(carbobenzyloxycarbonyl)valinyl]-3-amino-4-hydroxy-5-(2,3,5,6-tetrafluorophenyloxy)-pentanoic acid, tert-butyl ester (6.12 g, 10.50 mmol) in MeOH (300 ml) was added 10% palladium on carbon (0.92 g) at room temperature. The reaction was stirred for 3 hours under hydrogen (1 atm), then filtered through a pad of celite. The filter cake was washed with MeOH. The filtrate was concentrated in vacuo to provide the titled product as a viscous yellow oil (4.69 g, 10.30 mmol, 98%). MS C20H20N2O5, [M+Na]+ =475, [M−H]− =451.

1. filtrationfiltered through a pad of celite
2. washThe filter cake was washed with MeOH
3. concentrationThe filtrate was concentrated in vacuo