Methanol → HCID 86756381, compound

Participants

Reaction Steps

609 mg of 2,6,6-Trimethyl-10-(tetrahydro-pyran-2-yloxy)-dec-3-yn-2-ol (2.05 mmol) was dissolved in 13.5 ml of methanol, treated with 76 mg of pyridinium-(toluene-4-sulfonate) (0.15 eq.), and kept at room temperature for 1 night. The reaction mixture was then poured onto crushed ice/Na2CO3, extracted twice with ethylacetate, washed with brine, dried over sodium sulfate and evaporated to dryness. Flash chromatography (SiO2, hexane/ethylacetate=7/3) produced 413 mg of the title compound as yellowish oil.

Provenance & Evidence